Opener Babar Azam top-scored with an unbeaten 68 off 55 balls while Mohammad Hafeez made 39 off 30 deliveries at Sheikh Zayed Stadium.
Fast bowlers Billy Stanlake (3-21) and Andrew Tye (3-24) were the main wicket-takers for Australia.
The second and third matches will be played in Dubai on Friday and Sunday.
Earlier, Australia captain Aaron Finch won the toss and chose to bowl first in the first Twenty20 match against Pakistan in Abu Dhabi.
Finch’s side is unchanged from the XI that defeated the UAE by seven wickets on Monday.
The bowling line-up will consist of paceman Billy Stanlake, Nathan Coulter-Nile and Andrew Tye, with Adam Zampa and Ashton Agar to provide the spinning options.
Fakhar Zaman and Babar Azam are scheduled to open the Pakistan innings, with the experienced Sarfraz Ahmed named as captain and wicketkeeper.
Playing XI
Pakistan
Fakhar Zaman, Babar Azam, Hussain Talat, Sarfraz Ahmed (c,wk), Mohammad Hafeez, Asif Ali, Imad Wasim, Shadab Khan, Faheem Ashraf, Hasan Ali, Shaheen Afridi
Australia
Aaron Finch (c), D’Arcy Short, Chris Lynn, Glenn Maxwell, Ben McDermott, Alex Carey (wk), Ashton Agar, Nathan Coulter-Nile, Andrew Tye, Adam Zampa, Billy Stanlake